PRA rcd4
Background
Progressive Retinal Atrofy (PRA) is a common hereditary illness which leads to blindness. The blindness develops quickly or slowly depending on the mutant. A large number of types of PRA are now known in several breeds. (Scientific) research is continously carried out to develop new tests.
Age
The illness occurs at different ages, it is difficult to estimate at what ages the first symptons will be visible. There are differences between sibling and breeds
Characteristic
This illness causes reduced vision or blindness.
Breed dependency
This test is suited for certain breeds and available for the following breeds:
Gordon Setter, Irish Setter, the above mentioned breeds are mentioned in this test because the mutant occurs in these breeds.
Sample material: for this examination the following material is accepted: sperm, blood EDTA, blood heparin, tissue, swab. The breeder always receives a report about the test which you can ask for when you are going to see the pups. It is even better to ask for a copy.
Examination for PRArcd4
A DNA test is availablle from anumber of labs to see whether a dog has this illness. Our club uses HTTPS://www.animaldnadiagnostics.co.uk. The test is done by the vet and sent to the lab.
Result:
An animal is free from and has two healthy alleles. When used for breeding the animal will not develop the disorder nor pass it on to the next generation.
An animal is carrier and has one healthy allele an one malfunctioning allele. The animal will transmit the mutant to half his descendants. Carriers can somtimes also suffer from the malfunctioning allele but will generaly have no symptons.
A affected has two malfunctioning alleles. The affected transmits the disorder to all their descendants in the next generation and will develop symptons typical for the disease.
Inheritance
T
this characteristic is inherited on a autosomnal recessive manner. This means that an animal can be free from (homozygot normal), affected (homozygot abnormal) or carrier (heterozygot) Carriers can spread the mutant without having any symptons;
Therefore it is important to find the carriers in order to stop the spreading.
PRA rcd4 and breeding
The club demands that the breeders have their breeding animals DNA tested, if both parents are free from than you can skip one generation and testing is not necessary, the second generation needs to be tested.
| Following combinations are allowed |
- clear X clear
- carrier X clear
- carrier x carrier is not allowed !!
- Breeding with a affected dog is not allowed!!
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| Thanks to this DNA test we can breed more conciously and avoid combinations that are not allowed. |
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